Possible Interaction: Estradiol and Glucose

“Supplementation of humans and rodents with 17beta-estradiol (E(2)) lowers the respiratory exchange ratio, the glucose rate of appearance and disappearance, and the metabolic clearance rate.”

“Concomitant estrogen treatment was found to be neuroprotective, as the severity of the insult on cell viability was decreased by 40% at 15 h and up to 71% at 72 h. Likewise, the addition of 17beta-estradiol decreased both the glucose use and lactate production of the cells.”

“ Estradiol reverses the effects of menopause on glucose and insulin metabolism, resulting in an increase in pancreatic insulin secretion and a decrease in insulin resistance, although other types of estrogen may not do this.”

“Although glucose and pyruvate concentrations were significantly increased by EB treatment, levels of lactate, the main energy source of spermatogenic cells, were unchanged.”

“Moreover, the addition of 10−8 M 17β-estradiol to INS-1 cells cultured in a high glucose medium markedly reduced cell death, AGTR1 and p47ph°x mRNA levels, and protein expression.”

“High glucose decreased bone formation and also decreased the osteogenic effects of 17β-estradiol (10-8M).”

“ Glucose decreased circulating oestradiol (P < 0.05) but not that of FSH or progesterone.”

“Ovarian steroid hormones, particularly estradiol , play a modulatory role in the ability of the female brain to utilize glucose.”

“Direct measurements of both cyclic nucleotides demonstrated that nanomolar concentrations of 17beta-oestradiol in the presence of 8 mM glucose increased cGMP levels, yet cAMP levels were unchanged.”

“It was found that (1) a 12-hr fast abolishes anorexic effects of EB, but leaves the inhibitory effects of glucose intact, (2) EB does not potentiate short-term effects of glucose, and (3) EB enhances delayed (22 hr after gavage) effects of glucose upon feeding.”