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Last Updated: 2 years ago

Possible Interaction: Estradiol and Genistein



Research Papers that Mention the Interaction

Moreover, co-treatment of cells with 17beta-estradiol (E2) and either GEN or DAI showed a slight additive effect as compared to EQ.
The Journal of Steroid Biochemistry and Molecular Biology  •  2010  |  View Paper
In this study, we evaluated whether dietary GEN can act in an additive manner with low circulating levels of 17beta-estradiol (E2).
Carcinogenesis  •  2006  |  View Paper
In combined studies with estradiol, genistein exerted additive effects with estradiol in vitro.
Toxicological sciences : an official journal of the Society of Toxicology  •  1999  |  View Paper
Therefore, genistein may block mammary epithelial cell growth by interfering with signal transduction events stimulated by estradiol or growth factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research  •  1996  |  View Paper
The anti-proliferative effect of genistein is inhibited by estradiol.
Gynecologic and Obstetric Investigation  •  2013  |  View Paper
High concentrations of genistein (100 μM) both in the presence and absence of 17β-estradiol also increased apoptosis; however, these changes were not correlated with the BAX/BCL-2 ratio or with phosphorylation of ERK1/2.
Anticancer research  •  2012  |  View Paper
Results: A significant decrease in cell proliferation was seen in MDA-MB-231 cells at low concentrations of genistein in the presence of 17β-estradiol , as compared to genistein alone.
Pharmacology  •  2009  |  View Paper
In contrast, genistein had differential effects on 17β‐estradiol– mediated PSA expressions.
Molecular carcinogenesis  •  2002  |  View Paper
Therefore, exposure of breast cancer cells to genistein results in elevated conversion of estradiol to estrogenically weaker or inactive metabolites.
Annals of the New York Academy of Sciences  •  2001  |  View Paper
Genistein significantly inhibited cell growth (IC50 around 10 microM) of MCF-7, MDAMB-231 and HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth-stimulatory effects exerted by estradiol and growth factors.
Cancer letters  •  1998  |  View Paper
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