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Last Updated: 2 months ago

Possible Interaction: Estradiol and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Transwell and western blot assays revealed that genistein could reduce the FAK expression levels and alleviate the damage to the HU-ESTs.
Cellular Physiology and Biochemistry  •  2018  |  View Paper
The anti-proliferative effect of genistein is inhibited by estradiol.
Gynecologic and Obstetric Investigation  •  2013  |  View Paper
CONCLUSIONS Estradiol valerate plus dienogest , but not raloxifene and genistein , increase serum high-sensitive C-reactive protein levels.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics  •  2005  |  View Paper
Therefore, exposure of breast cancer cells to genistein results in elevated conversion of estradiol to estrogenically weaker or inactive metabolites.
Treatment of MCF-7 cells with 100 nM genistein increased the conversion of estradiol to estrone up to 19.5% in 24 h. The effect of genistein on estrone formation in MDA-MB-231 cells resulted in 37.7% of the radioactivity being estrone.
Annals of the New York Academy of Sciences  •  2001  |  View Paper
Genistein is only a weak transcriptional activator and actually decreases ERE-CAT levels induced by 17-beta estradiol in the ER+ lines.
Anticancer research  •  2000  |  View Paper
Genistein significantly inhibited cell growth (IC50 around 10 microM) of MCF-7, MDAMB-231 and HBL-100 cell lines, but not of skin-derived fibroblasts and counteracted the growth-stimulatory effects exerted by estradiol and growth factors.
Cancer letters  •  1998  |  View Paper
Coumestrol, alpha-zearalenol, or genistein could produce beta-galactosidase activity comparable to estradiol, but these required concentrations 100 to 1000-fold greater than estradiol.
Steroids  •  1997  |  View Paper
In addition, prolonged exposure to genistein resulted in a decrease in estrogen receptor mRNA level as well as a decreased response to stimulation by estradiol.
We also found that genistein , though estrogenic, can interfere with the effects of estradiol.
Carcinogenesis  •  1996  |  View Paper
Moreover, co-treatment of cells with 17beta-estradiol (E2) and either GEN or DAI showed a slight additive effect as compared to EQ.
The Journal of Steroid Biochemistry and Molecular Biology  •  2010  |  View Paper
In this study, we evaluated whether dietary GEN can act in an additive manner with low circulating levels of 17beta-estradiol (E2).
Carcinogenesis  •  2006  |  View Paper
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