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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estradiol
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Furthermore, estradiol rapidly attenuates the K+-evoked increase of GABA in dialysate.”
Viral Vector-Mediated Overexpression of Estrogen Receptor-α in Striatum Enhances the Estradiol-Induced Motor Activity in Female Rats and Estradiol-Modulated GABA Release“These findings are compatible with the hypothesis that estradiol potentiates secretion of the inhibitory neurotransmitter gamma-amino-butyric acid (GABA) at auditory nerve synapses, leading to delayed synaptic conduction time.”
“Furthermore, the amount of both GABA and glutamate content decreased due to high dose of estradiol , while only GABA increased in Pilocarpine treated rats.”
Evaluating the role of astrocytes on &bgr;‐estradiol effect on seizures of Pilocarpine epileptic model“While the levels of CAT, SOD, POD and Estradiol (E2) were significantly increased in the both doses of GABA.”
“In the arcuate nucleus, a major regulator of anterior pituitary function, estradiol increases GABA synthesis, altering the morphology of neighboring astrocytes and reducing formation of dendritic spines synapses.”
“Using whole‐cell patch clamp recording, we found previously that 17β‐oestradiol (E2) rapidly altered γ‐aminobutyric acid ( GABA ) neurotransmission in hypothalamic neurones through a membrane oestrogen receptor (mER).”
“The time needed for the onset of 17 beta-estradiol effect on mIPSC amplitude was approximately 48 h. In the period of 9-11DIV, treatment with 17 beta-estradiol strongly reduced the tonic conductance activated by low GABA concentrations.”
“ Estradiol blocked MCAO-induced increases in GABA concentration only in dorsomedial cortex.”
“It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors.”
“In support of our hypothesis, the K+‐evoked increase in GABA , but not taurine or glutamate, was significantly attenuated 30 min after treatment with estradiol.”
“This suggests that estradiol , via its action on the oestrogen receptor, prolongs the developmental duration of depolarizing GABA.”
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