Possible Interaction: Estradiol and Calcium Supplement

“Pretreatment of estradiol-BSA triggered a low calcium influx, suggesting ahead low influx calcium played a critical role in the underlying protective mechanisms of estradiol.”

“In VSMC both cBA and estradiol , in their free or protein-bound forms induced a steep and immediate rise in intracellular calcium.”

“Sixty minutes of incubation with 17beta-estradiol (10(-5)mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium.”

“ CA 125 and oestradiol concentrations were negatively correlated, CA 15-3 and oestradiol concentrations were positively correlated.”

“17 beta-Estradiol inhibited calcium ion-induced contraction similarly in rings of omental artery from both nonpregnant and pregnant patients.”

“In common with other estrogens, transdermal estradiol inhibits bone resorption, as evidenced by reduction in urinary excretion of calcium and hydroxyproline and other metabolic markers of bone resorption, and small increases in bone mineral density (BMD) in postmenopausal women receiving long term treatment.”

“Finally, circulating estradiol might directly stimulate intestinal absorption of calcium and may therefore explain why the inverse association of calcium intake and glioma is confined to women.”

“CVCs were treated with 17 beta-estradiol at concentrations of 0, 5, and 10 nmol/L. Twenty-one days of 17 beta-estradiol treatment resulted in a significantly increased number of calcified nodules, visualized by von Kossa staining, as well as increased calcium content of the cultures.”

“ Estradiol (E(2)) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis.”

“Intraperitoneal … estradiol-17beta (E(2); 10 microg/g) evoked … increases of circulating plasma levels of calcium and phosphorus and a sustained increases of circulating plasma levels of PTHrP. However, a combined treatment of …(2) and PTHrP(7-34) evoked a markedly lower calcium response compared with E(2) alone.”

“Taken together, these data suggest that there is a developmental shift in the route of KA-induced intracellular calcium and estradiol modulates KA-induced intracellular calcium to a time restricted to early development, but whether this is the basis of the neuroprotective effect of estradiol remains to be determined.”