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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estradiol
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“The protective effects of estradiol on vasculature may partly be related to a reduction in ADMA levels.”
Plasma markers of NO synthase activity in women after ovarian hyperstimulation: influence of estradiol on ADMA“However, administration of estradiols reduced the levels of ADMA , total cholesterol, and low-density lipoprotein (LDL) cholesterol and inhibited endothelial senescence and atherosclerosis (all P < 0.01).”
“A negative significant correlation was found between estradiol and ADMA (p <0.05).”
“Pretreatment with 17beta-estradiol (0.1 or 0.3 mg/kg) significantly attenuated inhibition of vasodilator responses to acetylcholine and elevation of both ADMA and MDA concentration by LDL (P < 0.01).”
“These results suggest that estradiol possesses a protective effect on the endothelium and the protective effect is related to reduction of ADMA concentration by inhibition of lipid peroxidation.”
17beta-estradiol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
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