supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Apigenin significantly inhibited basal, 8BR, 22R, PREG, P4, and D4 stimulated DIOL production in rat immature Leydig cells.”
Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer.“ Beta-estradiol metabolism was notably inhibited with apigenin at high concentration.”
“Additionally, medium, and high doses of API significantly reduced the potentiation of estradiol on ER expression, attenuated the transmission of estrogen/ER signaling, thereby inhibiting the phosphorylation of ERK1/2 and JNK1/2/3 in the MAPK.”
“Besides, we found that API competitively bound to ER with estradiol , and showed a weak selectivity to ERβ.”
“In vivo data indicated that API treatment significantly inhibited the enhancement of estradiol on clinical symptoms.”
Apigenin Attenuates the Allergic Reactions by Competitively Binding to ER With Estradiol“It was shown that high doses of apigenin (50 μM) do not display estrogen-like activity and can suppress ER activation by 17β-estradiol.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback