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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Estradiol
supplement:
Androstenediol
Research Papers that Mention the Interaction
“Although 5-androstene-3beta,17beta-diol competed with estradiol-17beta for the estrogen receptor, this property was considerably reduced as a consequence of the introduction of a 7alpha-hydroxyl or 16alpha-hydroxyl group.”
Products of dehydroepiandrosterone metabolism by human mammary tumors and their influence on estradiol receptor binding“The apparent KM for oestradiol was 1.59 X 10(-6) M. All three androgens inhibited the metabolism of oestradiol …: ADIOL, 2.05 X 10(-6) M; DHA-S and DHA, 1.59 X 10(-6) M. However, ADIOL … oestradiol for the active enzyme site … sulphate was non-competitive.”
“ Estradiol levels showed negative correlations with androstenediol levels in the late menopausal transition and very early postmenopause (r=-0.452, p = 0.052 and r=-0.617, p = 0.006, respectively).”
Correlations of androstenediol with reproductive hormones and cortisol according to stages during the menopausal transition in Japanese women
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