Possible Interaction: Estradiol and Adrenocorticotropic Hormone

“Seven women with ovarian suppression oestradiol concentration < 175 pmol/l by day 28) had consistently lower mean ACTH concentrations at all time points than the four remaining women who had oestradiol concentrations 222-880 pmol/l by day 28.”

“The adult adrenal cells in the presence of ACTH showed a much higher cortisol-DHA secretion ratio (on average 60-hold higher) but the addition of oestradiol markedly reduced this ratio as in foetal cells.”

“During the application of ACTH free oestradiol increased from 21.3 +/- 5.7 to 25.5 +/- 7.1 ng/ml (P less than 0.025) in the patients without dexamethasone.”

“The mean change in estradiol concentration after ACTH stimulation at 1 year after diets began was also higher in the HID group (19.0 pg/mL) than that in the LID group (-5.6 pg/mL).”

“ Oestradiol suppressed the ACTH and corticosterone responses to restraint stress in the prepubertal female.”

“ Oestradiol caused dose‐dependent increases in basal plasma ACTH and corticosterone concentrations but decreased the ACTH response to restraint stress.”

“The in vivo administration of beacon[47-73] (3.5 nmol/100 body weight) elicited within 60 min a marked decrease in the plasma concentration of ACTH , aldosterone and corticosterone, and a moderate lowering of the blood levels of testosterone and estradiol.”

“A high physiological dose of estradiol significantly reduced the ACTH and cortisol responses to both stressors but did not affect Epi and NE responses.”

“We conclude that increased fetal cortisol and ACTH secretion at the end of gestation may be due to the combined effects of the gonadal steroids in that estradiol increases basal plasma ACTH secretion while androstenedione reduces cortisol negative feedback efficacy.”

“Although estradiol alone had no effect, estradiol prevented the increase in DHA obtained with ACTH.”