Possible Interaction: Estradiol and Adrenocorticotropic Hormone

“Furthermore, ACTH also significantly stimulated 17 beta-estradiol production.”

“Seven women with ovarian suppression oestradiol concentration < 175 pmol/l by day 28) had consistently lower mean ACTH concentrations at all time points than the four remaining women who had oestradiol concentrations 222-880 pmol/l by day 28.”

“The adult adrenal cells in the presence of ACTH showed a much higher cortisol-DHA secretion ratio (on average 60-hold higher) but the addition of oestradiol markedly reduced this ratio as in foetal cells.”

“During the application of ACTH free oestradiol increased from 21.3 +/- 5.7 to 25.5 +/- 7.1 ng/ml (P less than 0.025) in the patients without dexamethasone.”

“A high physiological dose of estradiol significantly reduced the ACTH and cortisol responses to both stressors but did not affect Epi and NE responses.”

“However, duration of estrus, concentrations of estradiol at proestrus and corticoid response to injection of ACTH were reduced.”

“Recent evidence suggests that the interaction between estradiol and ACTH might involve production of paracrine or autocrine substances in the fetal brain.”

“ Oestradiol suppressed the ACTH and corticosterone responses to restraint stress in the prepubertal female.”

“BACKGROUND/AIMS Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress.”

“ Oestradiol caused dose-dependent increases in basal plasma ACTH and corticosterone concentrations but decreased the ACTH response to restraint stress.”