Possible Interaction: Erythromycin and Potassium

“Exposure of cells to erythromycin reduced the HERG encoded potassium current in a concentration dependent manner with an IC50 of 38.9 ± 1.2 μM and Hill Slope factor of 0.4 ± 0.1.”

“ Erythromycin produced the prolongation of APD and the inhibition of potassium currents with a lag time after addition of the drugs, which suggested that erythromycin might not reach potassium channels from outside the ventricular cells.”