Possible Interaction: Erythorbic Acid and Vitamin C

“ Erythorbic acid and 3,4-dihydroxybenzoate suppressed the enzyme activity as well as AsA did.”

“ Ascorbic acid oxidation is competitively inhibited by isoascorbic acid , an epimer of ascorbic acid, while other tested reducing agents are inactive.”

“Furthermore, AsA and ErA inhibited each other's absorption.”

“In AsA-deficient guinea pigs, the absorption rates of both AsA and ErA were higher than those in normal ones.”

“The content of AsA in the tissues of the animals administered both AsA and ErA was lower than that of the animals administered only … administered both AsA and ErA during the repletion period was lower than that of the animals administered only AsA. These results suggest that ErA … AsA ….”

“The content of AsA in the tissues of the animals administered less than 5 mg ErA together with … was not significantly different from that of the animals administered 5 mg AsA. The administration of 100 mg ErA together … mg AsA caused a decrease in the … AsA in the tissues.”

“Feeding experiments with erythorbic acid indicate the availability of ascorbic acid being diminished by 40-60% when administered together with erythorbic acid.”

“In guinea pigs, depending on an exogenous supply of ascorbic acid, a possible interaction of erythorbic acid with absorption, transport through the cell membranes at the tissue level, or with catabolism of ascorbic acid has been investigated.”

“Kinetic data on the catabolism of ascorbic acid showed a significant reduction in half-life (50% of the dose excreted) of the vitamin caused by administration of erythorbic acid.”

“Thus, ingestion of erythorbic acid interacts with newly introduced ascorbic acid by enforcing the breakdown of ascorbic acid.”

“After a vitamin C depletion period of 12 days supplementing erythorbic acid (50 mg/day/kg bodyweight) over 16 days significantly accelerated the …) ascorbic aicd in guinea pigs in comparison to animals supplemented with ascorbic acid (5 mg/day/kg bodyweight), but this effect of erythorbic acid … ascorbic acid.”