Possible Interaction: Ergotamine and Sumatriptan

“On the contrary, chronic treatments of ergotamine and sumatriptan , both provided with a 5-HT1 agonist activity, induced a worsening of M in 134 M sufferers.”

“Both sumatriptan and ergotamine decreased arteriovenous anastomotic, but not capillary, blood flow in the head and body skin.”

“Analyses of triptans and ergotamine complemented each other and gave a stronger signal when analyzed together.”

“Although introduction of triptans marginalized use of ergotamine , nicergoline is used in cerebral metabolic-vascular disorders, and dementia.”

“ Sumatriptan should not be administered within 24 hours of your taking an ergotamine preparation (examples include Cafergot, Ergocaff PB, dihydroergotamine/DHE), and you must wait at least 6 hours after administering sumatriptan before taking any ergotamine preparation.”

“Taking sumatriptan and an ergotamine simultaneously or too close together may result in blood vessel spasm and, potentially, angina, heart attack, or stroke.”

“Given the apparent absence of vasoconstrictor activity both in meningeal and extracranial vessels, BIBN 4096 BS may provide an alternative for the treatment of migraine in those patients where triptans and ergotamine derivatives are contraindicated due to their side effects.”

“The use of sumatriptan is contraindicated within 24 hours of using ergotamine or ergotamine-type medications such as methysergide.”

“BACKGROUND The antimigraine drugs ergotamine and sumatriptan may cause angina-like symptoms, possibly resulting from coronary artery constriction.”