Possible Interaction: Ergotamine and Serotonin

“Co-application of ergotamine prevented the inhibitory action of 5-HT on the firing activity of CA3 pyramidal neurons but not of 5-HT neurons, indicating that ergotamine acted as a partial 5-HT1A receptor agonist in the dorsal hippocampus and as a full agonist at 5-HT1A autoreceptors.”

“In the rat dorsal hippocampus and dorsal raphe nucleus, the microiontophoretic application of ergotamine and 5-HT suppressed the firing activity of CA3 pyramidal neurons and 5-HT neurons, an effect antagonized by selective 5-HT1A receptor antagonists.”

“The most efficient antagonists in inhibiting the stimulatory effect of 5-HT were methysergide, methiothepin, mesulergine, metergoline, clozapine, ergotamine , and (+)-butaclamol.”

“The results indicated that sumatriptan and ergotamine progressively increase the peripheral expression of 5-HT (5-hydroxytryptamine, serotonin).”

“ Ergotamine abusers showed reduced 5-HT hand vein contraction during abuse, compared to seven days after ergotamine withdrawal.”

“Moreover, the reduced 5-HT responsiveness during ergotamine abuse may possibly be compatible with the chronic headache present in some abusers, the withdrawal headache attacks and the abuse itself.”

“By testing venomotor receptors (venous-constriction test), it was possible to show a potentiation of the venous constriction effect of serotonin by methysergide and ergotamine.”

“ Blood 5-hydroxytryptamine levels were reduced during migraine attacks in patients who had taken ergotamine.”

“Both ergotamine and dihydroergotamine inhibited 5-HT uptake by a non-competitive mechanism.”

“BOL, like ergotamine , failed also to prevent the chemoceptor stimulant action of serotonin in dogs.”

“ Ergotamine and tolazoline are relatively ineffective in modifying the vascular actions of HT.”

“In contrast to ergotamine , which decreased the inotropic effects of serotonin on the uterus, CPA had no anti-serotonin effects.”