Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Ergotamine and Norepinephrine

supplement:

Ergotamine

Research Papers that Mention the Interaction

The additive effect of noradrenaline and ergotamine may well explain its therapeutic action in the treatment of migraine.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
The amount of norepinephrine released into the perfusate from the isolated spleen after nerve stimulation is significantly increased by ergotamine (0.5 to 2 μg/min) but the concomitant organ contractions are not significantly inhibited and may even be enhanced at times.
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie  •  2004  |  View Paper
In the presence of ergotamine , the contractile response to noradrenaline was completely blocked not only in control animals, but also in animals treated with ANG II alone or in combination with minoxidil.
l -NAME and HOE 140 unmask a contractile response to noradrenaline in the presence of ergotamine which seems to be mediated not only by alpha-adrenoceptors, but may be compensated by an endothelial relaxation.
Pharmacological research  •  2000  |  View Paper
noradrenaline , or the alpha 1-adrenoceptor agonist 1-phenylephrine, increased the spontaneous electrical activity … the cells tested (94% and 72%), whilst application of the alpha 1-antagonist, ergotamine reduced the spontaneous activity of 44% of the cells tested and … excitation following VNAB stimulation for 84% of the cells examined.
Brain Research Bulletin  •  1991  |  View Paper
Ergotamine (3-10 micrograms/kg) inhibited the electrical stimulation-induced pressor and cardiac responses without modifying pressor responses of noradrenaline and tyramine in the pithed rat.
General pharmacology  •  1988  |  View Paper
Since the drug did not reduce the cardiac effects of isoprenaline or tyramine, it is concluded that ergotamine interferes with the release of noradrenaline from the cardioaccelerator nerve, mainly by stimulating the presynaptic dopaminergic receptors.
European journal of pharmacology  •  1979  |  View Paper
Ergotamine reduced responses to 5-HT and noradrenaline , but this was probably related to its cranial vasoconstrictor effects, especially in the external carotid circulation.
European journal of pharmacology  •  1978  |  View Paper