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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ergotamine
drug:
Norepinephrine
Research Papers that Mention the Interaction
“In the majority of cats, the depressor action of noradrenaline seen after giving ergotoxine or ergotamine is feeble or absent unless large doses are given (West5) but in occasional cats it is just as great as that of adrenaline (Burn and Hutcheon*).”
HAS NORADRENALINE A DEPRESSOR ACTION IN THE NORMAL ANIMAL?“The additive effect of noradrenaline and ergotamine may well explain its therapeutic action in the treatment of migraine.”
“ Ergotamine potentiates the pressor effects of epinephrine and nor-epinephrine and reverses the depressor effects of Isuprel and isopropyl nor-sympatol.”
“The amount of norepinephrine released into the perfusate from the isolated spleen after nerve stimulation is significantly increased by ergotamine (0.5 to 2 μg/min) but the concomitant organ contractions are not significantly inhibited and may even be enhanced at times.”
The effect of ergotamine on humoral and neuronal actions in the nictitating membrane and the spleen of the cat“In the presence of ergotamine , the contractile response to noradrenaline was completely blocked not only in control animals, but also in animals treated with ANG II alone or in combination with minoxidil.”
“l -NAME and HOE 140 unmask a contractile response to noradrenaline in the presence of ergotamine which seems to be mediated not only by alpha-adrenoceptors, but may be compensated by an endothelial relaxation.”
“… noradrenaline , or the alpha 1-adrenoceptor agonist 1-phenylephrine, increased the spontaneous electrical activity … the cells tested (94% and 72%), whilst application of the alpha 1-antagonist, ergotamine reduced the spontaneous activity of 44% of the cells tested and … excitation following VNAB stimulation for 84% of the cells examined.”
“ Ergotamine (3-10 micrograms/kg) inhibited the electrical stimulation-induced pressor and cardiac responses without modifying pressor responses of noradrenaline and tyramine in the pithed rat.”
“Since the drug did not reduce the cardiac effects of isoprenaline or tyramine, it is concluded that ergotamine interferes with the release of noradrenaline from the cardioaccelerator nerve, mainly by stimulating the presynaptic dopaminergic receptors.”
“ Ergotamine reduced responses to 5-HT and noradrenaline , but this was probably related to its cranial vasoconstrictor effects, especially in the external carotid circulation.”
“3 The pA2 value of ergotamine against noradrenaline was 8.8.”
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