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“However, these doses of clozapine as well as the high doses of ergotamine (300μgkg−1) and mesulergine (300 and 1000μgkg−1) also attenuated the tachycardic effects of isoprenaline.”
British journal of pharmacology • 1997 | View Paper
“ Isoprenaline caused relaxation and/or contraction depending on the vein, tone and dose; relaxation was blocked by pronethalol (pA2-6.51) and contractions were antagonized or reversed by ergotamine and phenoxybenzamine.”