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Discover Supplement-Drug Interactions

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Last Updated: 5 days ago

Possible Interaction: Ergosterol and Allicin



Research Papers that Mention the Interaction

The simultaneous addition of allicin was inhibitory to AmB-induced ergosterol enrichment in the vacuole membrane, resulting in increased sensitivity of the organelles to the disruptive action of AmB. Allicin was also inhibitory to ergosterol enrichment in the vacuole membrane that was achieved by its external addition to cells.
These findings suggest that allicin enhances AmB-induced vacuole membrane damage by inhibiting ergosterol trafficking from the plasma membrane to the vacuole membrane.
Planta medica  •  2009  |  View Paper
In agreement with these findings, allicin was found to inhibit ergosterol transport from the plasma membrane to the cytoplasm, which is considered to be a cellular protective response to AmB-induced vacuole disruption in S. cerevisiae.
The Journal of Antibiotics  •  2009  |  View Paper