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Last Updated: 2 years ago

Possible Interaction: Ergonovine and Oxytocin



Research Papers that Mention the Interaction

Ergometrine plus oxytocin and misoprostol plus oxytocin cause significant side effects.
Health technology assessment  •  2019  |  View Paper
Ergometrine plus oxytocin combination was more effective for preventing PPH ≥ 1000 mL than oxytocin.
ergometrine … oxytocin combination had the higher risk for vomiting (RR 3.10 (95% CI 2.11 to 4.56), high-quality evidence; 1.9% versus 0.… fever (RR 3.18 (95% CI 2.22 to 4.55), moderate-quality evidence; 11.4% versus 3.6%) when compared with oxytocin.
The Cochrane database of systematic reviews  •  2018  |  View Paper
There … ergometrine … oxytocin (RR 0.70, 95% CI 0.59 to 0.84, moderate certainty), carbetocin (RR 0.72, 95% CI 0.56 to 0.93, … misoprostol plus oxytocin (RR 0.70, 95% CI 0.58 to 0.86, low certainty) may reduce PPH ≥ 500 mL compared with oxytocin.
The Cochrane database of systematic reviews  •  2018  |  View Paper
However, in the oxytocin-pretreated myometrium, a synergistic response is evident, and the combination of oxytocin with either ergonovine or carboprost produces superior response compared with oxytocin alone.
We hypothesized that the use of ergonovine or carboprost in combination with oxytocin would improve contractility compared with oxytocin alone.
oxytocin (… ergonovine (2.13 [0.30], P < 0.001 [multiple comparisons adjusted P value, P < 0.001]), carboprost (1.88 [0.10], P < 0.001 [P < … (3.39 [0.32], P = 0.68 [P = 0.99]) and carboprost + HDOx (2.68 [0.30], P = 0.20 [P = 0.60]).
Anesthesia and analgesia  •  2015  |  View Paper
However, the use of prophylactic oxytocin was associated with fewer side effects, specifically … use to prevent PPH.There is no evidence of benefit when adding oxytocin … ergometrine compared to ergot alkaloids alone, and there may even be increased … associated with increased mean blood loss compared to ergot alkaloids alone.
The Cochrane database of systematic reviews  •  2013  |  View Paper
Ergonovine can be used for prevention of PPH but may be considered second choice to oxytocin owing to the greater risk of maternal adverse effects and of the need for manual removal of a retained placenta.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC  •  2009  |  View Paper
Use of a combined preparation of oxytocin and ergometrine resulted in the lowest blood losses.
British journal of obstetrics and gynaecology  •  1981  |  View Paper
Blood pressure was also raised in some patients following the use of intramuscular oxytocin and ergometrine (Syntometrine).
British journal of obstetrics and gynaecology  •  1979  |  View Paper
Oxytocin pretreatment significantly suppressed the mean amplitude of the myometrial contractions as compared to the controls when the … to oxytocin (1.02 vs 1.74 g; P < .0001), but not with further exposure to ergonovine (0.77 vs. 0.58 g; P = .….83 vs 0.94 g; P = .4).
Reproductive Sciences  •  2010  |  View Paper
Misoprostol, ergometrine and the combination of oxytocin + ergometrine were assessed as probably inferior whilst the combination of oxytocin + misoprostol was assessed as definitely inferior to oxytocin.
American journal of obstetrics and gynecology  •  2021  |  View Paper
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