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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epoprostenol
supplement:
Vitamin K
Research Papers that Mention the Interaction
“ Menadione also abolished the bradykinin-stimulated release of PGI2 from luminally perfused segments of the LAD.”
Endothelium-derived hyperpolarizing factor, but not nitric oxide or prostacyclin release, is resistant to menadione-induced oxidative stress in the bovine coronary artery“Therefore, vitamin K1 modulates the release of AA in vascular cells and thus inhibits the capacity of blood vessels to synthesize PGI2.”
“ Vitamin K1 (1-100 microM) inhibited the release of PGI2 and prostaglandin E2 (PGE2) by bovine aortic endothelial cells in culture, as measured by radioimmunoassay of 6-keto-prostaglandin F1 alpha (6-keto-PGE1 alpha) and PGE2.”
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