Possible Interaction: Epoprostenol and Vitamin E

“The vitamin E supplementation to LDL donors attenuated the increase in prostacyclin production both in smokers and nonsmokers.”

“Thus, further suggesting that vitamin E and Se may have a specific role in controlling TXA2 and PGI2 synthesis.”

“ Vitamin E enrichment has been shown to retard LDL oxidation, inhibit the proliferation of smooth muscle cells, inhibit platelet adhesion …, inhibit the expression and function of adhesion molecules, attenuate the synthesis of leukotrienes and potentiate the release of prostacyclin through up-regulating the expression … cytosolic phospholipase A2 and cyclooxygenase.”

“At a subthreshold concentration 200 and 2 microM, respectively, both alpha-tocopherol and quercetin essentially increased the antiplatelet effects of PGI2 , PGE1 and iloprost.”

“We have previously reported that vitamin E enrichment potentiates the arachidonic acid release as well as the spontaneous prostacyclin release in human endothelial cells.”

“These studies demonstrated that tocopherol potentiates basal PGI2 release in HUVEC and in contrast to its reported inhibitory role in rat platelets, myocardium and neutrophils, tocopherol stimulates phospholipase activity in HUVEC.”

“ Alpha-tocopherol produced stimulation of prostacyclin production which peaked at or near 0.5 mM. Plasminogen activator activity was markedly reduced by the addition of alpha-tocopherol.”

“The aortic production of prostacyclin was increased 1.5 times both by alpha-tocopherol and a tocotrienol mixture, suggesting a possible relevance to their hypotensive effect.”

“ Vitamin E at physiological doses significantly enhanced the production of PGI2 by aortic endothelial cells when added to the culture simultaneously with histamine, the Ca2+ ionophore A23187 (A23187), plasma-derived serum (PDS), or arachidonic acid.”

“However, effluent prostacyclin , detected as the stable metabolite 6-keto-PGF1 alpha by radioimmunoassay, was potentiated by dietary vitamin E in a dose-dependent manner.”