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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epoprostenol
supplement:
Vitamin C
Research Papers that Mention the Interaction
“In addition, from endogenous stores of AA in aortic rings ascorbic acid induced an increased generation of prostacyclin as revealed by inhibition of ADP-induced platelet aggregation.”
Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic rings.“ Vitamin C stimulated endothelial cell PGI2 production (80% at 10(-2) mol/l) but it could not counteract the inhibition of PGI2 production (83%) exerted by 10(-2) mol/l tert-butyl hydroperoxide (TBHP), a promoter of lipid peroxidation.”
“Pretreatment of EC with low concentrations of vitamin C inhibited the radiation induced release of PGI2 to the culture medium.”
Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C.
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