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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Epoprostenol and Secretin



Research Papers that Mention the Interaction

2) Secretin increased PGE and PGI2 metabolite 6-Keto-PGF1 alpha release significantly.
Sheng li xue bao : [Acta physiologica Sinica]  •  1989  |  View Paper
The kinetic analysis showed that the interaction between PGI2 and secretin affecting bicarbonate secretion is of a mixed type (increased half-maximal dose response, decreased calculated maximal response).
This indicates that PGI2 decreases both the total secretory capacity of the pancreas to secrete bicarbonate and reduces the sensitivity of the pancreatic secretory cells to secretin.
When given during stimulated pancreatic secretion, PGI2 caused a potent inhibition of the bicarbonate and protein secretion induced by feeding a liver meal, by duodenal perfusion with hydrochloric acid or amino acid mixture, and by intravenous infusion of secretin or caerulein.
The American journal of physiology  •  1980  |  View Paper