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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epoprostenol
supplement:
Quercetin
Research Papers that Mention the Interaction
“At a subthreshold concentration 200 and 2 microM, respectively, both alpha-tocopherol and quercetin essentially increased the antiplatelet effects of PGI2 , PGE1 and iloprost.”
Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin.“Our data indicate that quercetin modulates the release of ET-1, t-PA, and PGI2 from vascular endothelial cells.”
“ Quercetin (1, 5, and 20 microM) inhibited PGI2 , in a concentration-dependent manner (n = 6, P < 0.05).”
“We now report that (1) high concentrations of quercetin raise platelet cAMP levels; and (2) quercetin potentiates the inhibitory effect of prostacyclin (PGI2) on ADP-induced washed human platelet aggregation and the elevation of platelet cAMP levels elicited by PGI2.”
“In contrast procaine and quercetin selectively inhibit the ACh-mediated component of PGI2 action.”
“ Quercetin (1 and 5 μol/l) inhibited the effect of PGI2 and, at higher concentrations, it also caused partial depression of the responses to ACh.”
Target sites for the inhibition of prostacyclin effect in guinea-pig ileum
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