Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Epoprostenol and Quercetin



Research Papers that Mention the Interaction

At a subthreshold concentration 200 and 2 microM, respectively, both alpha-tocopherol and quercetin essentially increased the antiplatelet effects of PGI2 , PGE1 and iloprost.
Platelets  •  2004  |  View Paper
Our data indicate that quercetin modulates the release of ET-1, t-PA, and PGI2 from vascular endothelial cells.
Quercetin (1, 5, and 20 microM) inhibited PGI2 , in a concentration-dependent manner (n = 6, P < 0.05).
Journal of ethnopharmacology  •  1999  |  View Paper
We now report that (1) high concentrations of quercetin raise platelet cAMP levels; and (2) quercetin potentiates the inhibitory effect of prostacyclin (PGI2) on ADP-induced washed human platelet aggregation and the elevation of platelet cAMP levels elicited by PGI2.
Biochemical pharmacology  •  1982  |  View Paper
In contrast procaine and quercetin selectively inhibit the ACh-mediated component of PGI2 action.
Quercetin (1 and 5 μol/l) inhibited the effect of PGI2 and, at higher concentrations, it also caused partial depression of the responses to ACh.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper