Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 9 months ago

Possible Interaction: Epoprostenol and Masoprocol



Research Papers that Mention the Interaction

For example, NDGA inhibited arachidonic acid-stimulated release with a 50% inhibitory concentration (IC50) of 0.39 microM for PGI2 , 0.25 microM for 15-HETE, and 0.10 microM for 12-HETE.
The American journal of physiology  •  1989  |  View Paper
This could indicate that NDGA might exert its effect on prostacyclin levels by preventing the synthesis of 15-hydroperoxyeicosatetraenoic acid (15-HPETE), a potent inhibitor of prostacyclin synthetase.
Biochimica et biophysica acta  •  1986  |  View Paper
5 The antioxidant‐lipoxygenase inhibitor, nordihydroguiaretic acid (NDGA, 3–15 μm) likewise augmented rat mucosal prostacyclin formation.
British journal of pharmacology  •  1983  |  View Paper