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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epoprostenol
supplement:
Masoprocol
Research Papers that Mention the Interaction
“For example, NDGA inhibited arachidonic acid-stimulated release with a 50% inhibitory concentration (IC50) of 0.39 microM for PGI2 , 0.25 microM for 15-HETE, and 0.10 microM for 12-HETE.”
Regulation of synthesis of prostacyclin and HETEs in human endothelial cells.“This could indicate that NDGA might exert its effect on prostacyclin levels by preventing the synthesis of 15-hydroperoxyeicosatetraenoic acid (15-HPETE), a potent inhibitor of prostacyclin synthetase.”
Possible inhibitory function of endogenous 15-hydroperoxyeicosatetraenoic acid on prostacyclin formation in bovine aortic endothelial cells.“5 The antioxidant‐lipoxygenase inhibitor, nordihydroguiaretic acid (NDGA, 3–15 μm) likewise augmented rat mucosal prostacyclin formation.”
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