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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epoprostenol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Both are strongly reduced if Ca2+ addition is preceded by SNP or PGI2.”
Ca2+ influx in platelets: activation by thrombin and by the depletion of the stores. Effect of cyclic nucleotides.“One of them, cAMP regulation, is coupled with a potent inhibiting effect of prostacyclin , an adenylate cyclase activator, on Ca2+in increase in stimulated neutrophils.”
“A low-dose infusion of calcium or norepinephrine (known stimulants of prostacyclin) increased renal prostacyclin release in normal subjects and controls with renal insufficiency.”
“ Ca++ can stimulate prostaglandin E2 (PGE2) and/or prostacyclin (PGI2) release in vitro, which may modulate Ca++ vascular effects.”
“alpha 2-Adrenoceptor stimulation in platelets showed an increased sensitivity to adrenaline, as determined by sensitivity in counteracting the inhibitor effect of PGI2 on intracellular free calcium concentration in untreated patients with essential hypertension, when compared with treated patients or normotensive subjects.”
“Therefore, it is probable that calcium ions and calcium-activated calmodulin play a role in the effect of prostacyclin.”
Cytoprotection and intracellular calcium“P uterine artery prostacyclin production increased similarly with ANG II (61%) and A23187 (78%) in the presence of calcium (2 mM), whereas NP uterine arteries responded only to A23187 (71%).”
“In this preparation PGI2 increased the calcium current in a concentration-dependent manner, by up to 60% over the control value (at 10 microM), whereas PGE1 (tested in the range 1 nM-10 microM) had practically no effect on the calcium current.”
“ PGI2 (tested in the range 1 nM-10 microM) had marked effects on both action potential and calcium current.”
“These data indicate that the positive inotropic effect exerted by PGI2 on cardiac preparations is probably due to enhancement in the calcium current via a cAMP-dependent phosphorylation of the calcium channel.”
“Application of PGI2 reduced the depth of ischemia-evoked drop of Ca2+e by 50% without accelerating recovery during recirculation; the post-ischemic increase of BBB permeability to fluorescein was also diminished.”
“Moreover myocardial intracellular calcium availability seems to be influenced by PGI2.”
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