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Last Updated: 2 years ago

Possible Interaction: Epoetin Alfa and Iron, Dietary

Research Papers that Mention the Interaction

Factors that influence the response to epoetin alfa include the dose and timing of treatment (20), coadministration of iron (21, 22), and baseline hemoglobin concentration (23).
Thus, a person weighing 70 kg would require a total dose of 168 000 U. … subgroup analysis from a previous study (18), we hypothesized that a high dose of oral iron used in … more prolonged epoetin alfa dosing schedule might produce a better … that obtained with the standard regimen.
Annals of Internal Medicine  •  2000  |  View Paper
Iron availability was a critical factor in determining the response to epoetin alfa.
Seminars in hematology  •  1996  |  View Paper
That iron and especially intravenous iron was underused in the EPO group is clear from the rate of both enteric and intravenous iron therapy.
The study design recognized that the availability of iron is a limiting factor in the response to EPO and suggested that, “Patients with transferrin saturation value of less than 20% were to receive iron supplementation”.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology  •  2016  |  View Paper
Response to treatment with iron and epoetin is multifactorial, and results are still far from the targets set by the guidelines.
Journal of nephrology  •  2006  |  View Paper
ascorbic acid therapy in iron overloaded HD patients receiving Epoetin alfa.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association  •  2000  |  View Paper
It is also increasingly recognized that IV iron can enhance the response to epoetin , even in iron-replete patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1999  |  View Paper
iron almost certainly outweigh the risks in terms of optimizing the response to epoetin therapy.
Kidney international. Supplement  •  1999  |  View Paper
Resistance to epoetin may be due to iron or vitamin deficiency, natural or exogenous inhibitors of erythropoiesis and bone marrow fibrosis.
PharmacoEconomics  •  1994  |  View Paper
Epoetin alfa stimulates erythropoiesis, thus creating an increased need for iron , and virtually all patients with end-stage renal disease who receive this therapy will eventually require iron supplementation.
ANNA journal  •  1993  |  View Paper
Stimulation of erythropoiesis by Epoetin alfa causes an increased demand for iron to facilitate hemoglobin synthesis.
ANNA journal  •  1990  |  View Paper