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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Vitamin E

supplement:

Vitamin E

Research Papers that Mention the Interaction

Vitamin E (tocopherol) enhances the growth inhibitory effects of adriamycin (ADR) on a variety of cancer cells in vitro.
The Journal of urology  •  1986  |  View Paper
Preincubation of PMNLs with vitamin E partially protected them from the effects of Adriamycin.
Journal of clinical & laboratory immunology  •  1983  |  View Paper
In six controls who ingested 1,600 units vitamin E daily for two weeks, platelet MDA formation induced by N-ethyl maleimide, thrombin, and Adriamycin was decreased by 11-20%.
American journal of hematology  •  1978  |  View Paper
At this dose of ADR , however, the protection afforded by CoQ and Vit E was minimal and not statistically significant (p less than 0.05).
  •  1979  |  View Paper
However, when the animals were pretreated with (+)-alpha-tocopherol acid succinate or superoxide dismutase before ADM administration apoptotic index significantly diminished (P<0.05) and the DNA electrophoresis did not show fragmentations.
Cancer letters  •  2005  |  View Paper
ADR injected rats showed a significant decline in the activities of enzymic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymic antioxidants (reduced glutathione, Vitamin A, Vitamin C and Vitamin E ) with high malondialdehyde levels.
Molecular and cellular biochemistry  •  2004  |  View Paper
CONCLUSION Dietary supplementation of vitamin E protects the activities of antioxidant enzymes in the kidney cortex and glomeruli, and attenuates the evolution towards terminal renal failure in rats treated with Adriamycin.
Nephron  •  2002  |  View Paper
In this study, we have established that vitamin E has some beneficial effects on the kidney by protecting it from some of the toxicity induced by Adriamycin.
We found that vitamin E administered together with Adriamycin could reverse some of the degenerative changes caused by Adriamycin.
Nephron  •  1999  |  View Paper
These results suggest that vitamin E may play a role in enhancing the cytotoxic effects of adriamycin , but may not have any protective effect on normal cells as previously suggested through in vitro methods.
Vitamin E has been shown to enhance the growth-inhibitory effects of adriamycin on human prostatic carcinoma cells in vitro.
Journal of surgical oncology  •  1988  |  View Paper
The results revealed that Vitamin E treatment does indeed reduce Adriamycin toxicity and adds to tumor reduction and decrease metastasis.
Vitamin E also enhances the efficacy of Cyclophosphamide, Adriamycin and Methotrexate.
In vivo  •  1988  |  View Paper
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