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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Epirubicin
supplement:
Vitamin E
Research Papers that Mention the Interaction
“ Vitamin E (tocopherol) enhances the growth inhibitory effects of adriamycin (ADR) on a variety of cancer cells in vitro.”
Vitamin E enhances the chemotherapeutic effects of adriamycin on human prostatic carcinoma cells in vitro.“Preincubation of PMNLs with vitamin E partially protected them from the effects of Adriamycin.”
“In six controls who ingested 1,600 units vitamin E daily for two weeks, platelet MDA formation induced by N-ethyl maleimide, thrombin, and Adriamycin was decreased by 11-20%.”
“At this dose of ADR , however, the protection afforded by CoQ and Vit E was minimal and not statistically significant (p less than 0.05).”
Coenzyme Q10 or α-tocopherol reduce the acute toxicity of anthramycin in mice“However, when the animals were pretreated with (+)-alpha-tocopherol acid succinate or superoxide dismutase before ADM administration apoptotic index significantly diminished (P<0.05) and the DNA electrophoresis did not show fragmentations.”
In vivo modification of adriamycin-induced apoptosis in L-5178Y lymphoma cell-bearing mice by (+)-alpha-tocopherol and superoxide dismutase.“ ADR injected rats showed a significant decline in the activities of enzymic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymic antioxidants (reduced glutathione, Vitamin A, Vitamin C and Vitamin E ) with high malondialdehyde levels.”
“CONCLUSION Dietary supplementation of vitamin E protects the activities of antioxidant enzymes in the kidney cortex and glomeruli, and attenuates the evolution towards terminal renal failure in rats treated with Adriamycin.”
“In this study, we have established that vitamin E has some beneficial effects on the kidney by protecting it from some of the toxicity induced by Adriamycin.”
“We found that vitamin E administered together with Adriamycin could reverse some of the degenerative changes caused by Adriamycin.”
“These results suggest that vitamin E may play a role in enhancing the cytotoxic effects of adriamycin , but may not have any protective effect on normal cells as previously suggested through in vitro methods.”
“ Vitamin E has been shown to enhance the growth-inhibitory effects of adriamycin on human prostatic carcinoma cells in vitro.”
“The results revealed that Vitamin E treatment does indeed reduce Adriamycin toxicity and adds to tumor reduction and decrease metastasis.”
“ Vitamin E also enhances the efficacy of Cyclophosphamide, Adriamycin and Methotrexate.”
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