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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Triptolide Analog

Research Papers that Mention the Interaction

Furthermore, we found that TPL restored the sensitivity DU145/ADM cells to ADM in a dose dependent manner, and this was accompanied by the inhibition of MDR1 expression at both mRNA and protein levels.
Neoplasma  •  2013  |  View Paper
The results showed that TPL significantly decreased the resistance degree of K562/A02 cells, inhibited P-glycoprotein expression (mean fluorescent intensity decreased from 123 ± 13 to 39 ± 13) and increased the intracellular concentration of ADM (mean fluorescent intensity increased from 18 ± 5 to 34 ± 6) in K562/A02 cells.
Zhongguo shi yan xue ye xue za zhi  •  2012  |  View Paper
DISCUSSION AND CONCLUSION Our findings indicated that triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression.
RESULTS TPL (5 nmol/L) increased the sensitivity of K562/A02 to adriamycin.
When adriamycin was combined with 5 nmol/L TPL , the mean apoptotic population of K562/A02 cells was increased from 4.3 to 18.5%, respectively.
Pharmaceutical biology  •  2012  |  View Paper
Results revealed that triptolide decreased the degree of resistance of K562/A02 cells, and significantly inhibited P-glycoprotein expression and drug-transport function, and increased the accumulation of adriamycin in K562/A02 cells as measured by flow cytometry.
Triptolide may effectively reverse the adriamycin resistance in K562/A02 cells via modulation of the P-glycoprotein expression and by increasing intracellular adriamycin accumulation.
Oncology letters  •  2012  |  View Paper