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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Epirubicin
supplement:
Triptolide Analog
Research Papers that Mention the Interaction
“Furthermore, we found that TPL restored the sensitivity DU145/ADM cells to ADM in a dose dependent manner, and this was accompanied by the inhibition of MDR1 expression at both mRNA and protein levels.”
“The results showed that TPL significantly decreased the resistance degree of K562/A02 cells, inhibited P-glycoprotein expression (mean fluorescent intensity decreased from 123 ± 13 to 39 ± 13) and increased the intracellular concentration of ADM (mean fluorescent intensity increased from 18 ± 5 to 34 ± 6) in K562/A02 cells.”
“DISCUSSION AND CONCLUSION Our findings indicated that triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression.”
“RESULTS TPL (5 nmol/L) increased the sensitivity of K562/A02 to adriamycin.”
“When adriamycin was combined with 5 nmol/L TPL , the mean apoptotic population of K562/A02 cells was increased from 4.3 to 18.5%, respectively.”
Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression“Results revealed that triptolide decreased the degree of resistance of K562/A02 cells, and significantly inhibited P-glycoprotein expression and drug-transport function, and increased the accumulation of adriamycin in K562/A02 cells as measured by flow cytometry.”
“ Triptolide may effectively reverse the adriamycin resistance in K562/A02 cells via modulation of the P-glycoprotein expression and by increasing intracellular adriamycin accumulation.”
Modulation of P-glycoprotein expression by triptolide in adriamycin-resistant K562/A02 cells.
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