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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Riboflavin

supplement:

Riboflavin

Research Papers that Mention the Interaction

Adriamycin produced saturable, concentration-dependent upfield shifts of the proton signals of both FMN and FAD.
These results suggest complex formation between Adriamycin and FMN or FAD via π-π ring stacking interactions occurring between the anthracycline ring of Adriamycin and the isoalloxazine ring of the flavins.
Archives of biochemistry and biophysics  •  1981  |  View Paper
Abstract The addition of Adriamycin to a solution containing flavin mononucleotide (FMN) resulted in an upfield shift in the signals of the aromatic ring protons H(6,9) and the 8α, 7α methyl protons of FMN.
These results suggest that FMN and Adriamycin form a complex via ring-ring stacking.
Biochemical and biophysical research communications  •  1980  |  View Paper
The present investigation determined that ADR administration inhibited flavin adenine dinucleotide (FAD) biosynthesis from riboflavin in rat skeletal muscle in a dose-related manner compared to results in pair-fed controls.
Biochemical pharmacology  •  1988  |  View Paper
Adriamycin has been shown to form a 1:1 stoichiometric complex with riboflavin , as well as to compete for binding to tissue proteins.
These findings in an animal model raise the possibility that defects of riboflavin nutriture, either dietary or drug-induced, may be a determinant of Adriamycin toxicity.
Cancer  •  1986  |  View Paper