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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epirubicin
supplement:
Quinine
Research Papers that Mention the Interaction
“In the observed time interval of 24 h, the red blood cell coefficient of distribution kRBC of EPR was lower if QUI was coadministered (kRBC = 1.25 ± 0.12 for the control group kRBC = 1.15 ± 0.13 under QUI; p < 0.04).”
“ QUI caused a reduction of the serum bioavailability of EPR (expressed as AUC0-24-values) from 3404 ± 1008 ng/ml × h to 2359 ± 1073 ng/ml × h (-3 1 % , p < 0.05).”
“ QUI possesses a statistical significant influence on the EPR serum concentrations and, as a consequence, on the pharmacokinetic parameters for the initial distribution phase of EPR.”
“The results point out that QUI induces an accelerated distribution of EPR from the blood into the tissue and that QUI additionally may have influence on the red-blood cell partitioning of EPR.”
Pharmacokinetic Interaction between 4′-Epidoxorubicin and the Multidrug Resistance Reverting Agent Quinine“ Quinine , the widely used antimalaria agent, was found to increase the cytotoxicity of epideoxorubicin (epiDXR) in resistant DHD/K12 rat colon cancer cells in vitro.”
Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice.
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