Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epirubicin and Quercetin



Research Papers that Mention the Interaction

Flow cytometry showed that the quercetin increased the accumulation of ADR in K562/A cells when cells were co-cultured with 5 µmol/L ADR for 2 hours.
Quercetin increased the sensitivity of K562/A cells to ADR in a low toxicity concentration.
Zhongguo shi yan xue ye xue za zhi  •  2011  |  View Paper
These results indicate that quercetin may be capable of reversing MDR and synergizing the inhibitory activity of Adriamycin on the growth of MCF-7 AdrR cells.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
This study demonstrates that the flavonoid quercetin (Q), a plant-derived compound with low toxicity in vivo, greatly potentiates the growth-inhibitory activity of Adriamycin (ADR) on MCF-7 ADR-resistant human breast cancer cells.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
Co-treatment with quercetin achieved a similar suppression of leukemic cell proliferation when a lower dose of Adriamycin (0.03, 0.3 or 3 µg/ml) was administered for the same duration.
Compared with treatment with Adriamycin alone, the combined treatment with Adriamycin and quercetin significantly enhanced the SOD activity and reduced the MDA content in the heart.
The survival of non-irradiated mice with T-ALL was improved by co-treatment with a high dose of Adriamycin and quercetin compared with either treatment alone.
Therefore, quercetin may enhance the effects of Adriamycin on refractory acute leukemia.
Oncology letters  •  2019  |  View Paper
Que could sensitize the anti-leukemic effect of ADM by inhibiting the proliferation of white blood cells through trapping the cells …; caspase-3 was activated via the expressional regulation of Bcl-2, Bax, and NF-κB. When applied in combination with ADM, Que could attenuate heart … reactive oxygen species.
Results Compared with ADM group, the combination of ADM and Que showed prolonged survival time and less peripheral white blood cells.
Hematology  •  2015  |  View Paper
It is concluded that through modulating the expression of apoptosis-related genes, the quercetin can inhibit leukemia cell proliferation, promote apoptosis, and enhance the chemotherapeutic effects of adriamycin.
Quercetin and adriamycin alone or in their combination could reduce the ratio of G0/G1 phase in mice, the cell ratio in S phase and G2/M phase increased, and the effects of the combination group were more significant than that of the single agent groups.
The results indicated that the quercetin and adriamycin could significantly prolong the survival of P388 leukemia nude mice, and their combination displayed significantly prolonged effect.
Zhongguo shi yan xue ye xue za zhi  •  2014  |  View Paper
Quercetin decreased the ADR accumulation in the wild type cells but did not affect it in the ADR-resistant cells.
These results indicated that quercetin decreased ADR accumulation without extruding ADR in the wild type EAT cells.
…,ADR accumulation in the … with 50 microM quercetin for 7 days, increased to 186.6% and to 181.9% of that in untreated cells after 60 minutes and 120 …, whilst it increased to 70% from 37.5% of that in the wild type EAT cells after 60 minutes incubation.
Anticancer research  •  2000  |  View Paper