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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Epirubicin
supplement:
Progesterone
Research Papers that Mention the Interaction
“CONCLUSIONS Our observations suggest that pr gesterone en hances the efficacy of epi rubicin. ”
“This study investigated the therapeutic potential of combination of progesterone and epirubicin in the treatment of the human hepatoma cell line HA22T/VGH and the possible mechanisms through which this combination might induce apoptosis.”
Progesterone augments epirubicin-induced apoptosis in HA22T/VGH cells by increasing oxidative stress and upregulating Fas/FasL.“Addition of 30 μM progesterone , which was inactive alone, augmented the effect of epirubicin on the inhibition of growth of HA22T/VGH cells.”
“RESULTS 50 microM pr gesterone in creased both the cytotoxic and apoptotic effects of 0.1 microg/ml epi rubicin on HepG2 cells at 48 hr culture due to 50 microM progesterone accumulated cells in S phase of the cell cycle and subsequently reduced cyclin D1 expression.”
“In conclusion, our results demonstrate that progesterone , acacia, Tween 20 and Tween 80 are potent MDR modifiers of epirubicin in Caco-2 at concentrations that could be achieved in vivo.”
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