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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Epirubicin
supplement:
Phosphatidylserine
Research Papers that Mention the Interaction
“Half-maximal inhibition (IC50 value) … 200 microM. However, preincubation of ADR … ( PS ) or PKC enzyme, prior to the enzyme assay, reduced the IC50 value from 200 microM to 52 microM or …, indicating an affinity of ADR for PS, and also a possible action site for ADR on PKC molecules.”
Adriamycin interacts with diacylglycerol to inhibit human leukemia protein kinase C.“ Adriamycin decreased the rate of ascorbate permeation into the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposomes and DPPC liposomes containing small amounts of phosphatidylglycerol or phosphatidylserine.”
Adriamycin-liposome interactions. A magnetic resonance study of the differential effects of cardiolipin on drug-induced fusion and permeability.“Concomitantly, the concentration of ADM in the heart was significantly diminished when the drug was delivered by PS :PC:Chol and PC:Chol liposomes but only slightly reduced when DPG:PC:Chol liposomes were used.”
“Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3- to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without cholesterol (Chol).”
Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.“In both phosphorylation systems, the inhibition by adriamycin was reversed by either phospholipid ( phosphatidylserine or cardiolipin) or calmodulin respectively.”
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