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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Phosphatidylserine

Research Papers that Mention the Interaction

Half-maximal inhibition (IC50 value) … 200 microM. However, preincubation of ADR … ( PS ) or PKC enzyme, prior to the enzyme assay, reduced the IC50 value from 200 microM to 52 microM or …, indicating an affinity of ADR for PS, and also a possible action site for ADR on PKC molecules.
Anticancer research  •  1989  |  View Paper
Adriamycin decreased the rate of ascorbate permeation into the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposomes and DPPC liposomes containing small amounts of phosphatidylglycerol or phosphatidylserine.
Biochimica et biophysica acta  •  1982  |  View Paper
Concomitantly, the concentration of ADM in the heart was significantly diminished when the drug was delivered by PS :PC:Chol and PC:Chol liposomes but only slightly reduced when DPG:PC:Chol liposomes were used.
Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3- to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without cholesterol (Chol).
Cancer research  •  1982  |  View Paper
In both phosphorylation systems, the inhibition by adriamycin was reversed by either phospholipid ( phosphatidylserine or cardiolipin) or calmodulin respectively.
The Biochemical journal  •  1981  |  View Paper