supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Epirubicin
supplement:
Melatonin
Research Papers that Mention the Interaction
“ DXR treatment increased cell death and mitochondrial fission which were reduced with melatonin treatment.”
“Furthermore, DXR + melatonin treatment increased cellular ATP levels, PGC1‐&agr; and SIRT1 expression which was attenuated by DXR treatment.”
“ Melatonin improves cardiac function and reduces apoptosis during DXR treatment.”
Melatonin improves cardiac and mitochondrial function during doxorubicin‐induced cardiotoxicity: A possible role for peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha and sirtuin activity?“We conclude that the epirubicin increased the nitrozative stress, not the oxidative stress, in heart tissue, and the cardioprotective effect of melatonin was partially attributed to the suppression of epirubicin-induced nitrozative stress.”
“Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp.”
“Results Melatonin significantly enhanced the epirubicin-induced cell proliferation suppression, epirubicin-induced apoptosis, and reduced the IC50 value of epirubicin.”
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback