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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Linolenic Acid

supplement:

Linolenic Acid

Research Papers that Mention the Interaction

Replacement of Asn(1245) with Ala also decreased resistance to VP-16, doxorubicin, and epirubicin but increased resistance to vincristine.
The Journal of Biological Chemistry  •  2002  |  View Paper
Addition of more than 10 microM of adriamycin to cultured rat hepatocytes loaded with alpha-linolenic acid (linolenic acid-loaded hepatocytes) caused marked lipid peroxidation as measured by an accumulation of malondialdehyde during a 9 hr incubation.
After addition of 50 microM of adriamycin to linolenic acid-loaded hepatocytes, malondialdehyde accumulation significantly increased at 3 hr, followed by cellular reduced glutathione decrease and lactate dehydrogenase leakage after 6 hr.
Pharmacology & toxicology  •  1998  |  View Paper