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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Epirubicin
supplement:
Linolenic Acid
Research Papers that Mention the Interaction
“Replacement of Asn(1245) with Ala also decreased resistance to VP-16, doxorubicin, and epirubicin but increased resistance to vincristine.”
Determinants of the Substrate Specificity of Multidrug Resistance Protein 1“Addition of more than 10 microM of adriamycin to cultured rat hepatocytes loaded with alpha-linolenic acid (linolenic acid-loaded hepatocytes) caused marked lipid peroxidation as measured by an accumulation of malondialdehyde during a 9 hr incubation.”
“After addition of 50 microM of adriamycin to linolenic acid-loaded hepatocytes, malondialdehyde accumulation significantly increased at 3 hr, followed by cellular reduced glutathione decrease and lactate dehydrogenase leakage after 6 hr.”
Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes.
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