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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Levocarnitine



Research Papers that Mention the Interaction

We determined whether addition of l-carnitine altered the tumor cytotoxic effects of epirubicin using a number of in vitro cell viability assays in different breast cancer cell lines including BT549, MDA-MB-435, NCI-ADR-RES, MCF7 and T47D.
Cancer letters  •  2007  |  View Paper
This mechanism can be proposed to explain the protective effects of L-carnitine against adriamycin cardiotoxicity, ammonium acetate and zidovudine-induced mitochondrial ultrastructural and functional alterations.
Drugs under experimental and clinical research  •  2001  |  View Paper
ADR treatment resulted in elevation of plasma free and total CARN concentrations (p < 0.05).
Pediatric Research  •  2003  |  View Paper
However, the oxidation of a non-CPT 1 dependent substrate palmitoylcarnitine was unaffected by adriamycin except … than 1 mM. These data suggest that after in vitro or in vivo administration, adriamycin , inhibits fatty acid oxidation in part secondary to … 1 and/or depletion of its substrate, L-carnitine , in ….
Interestingly, medium- and short-chain fatty acid oxidation, which are independent of CPT 1, were also inhibited acutely by adriamycin and could be reversed by L-carnitine.
Journal of molecular and cellular cardiology  •  1997  |  View Paper