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Last Updated: 2 months ago

Possible Interaction: Epirubicin and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

Epirubicin treatment also decreased glutathione resulting in the induction of apoptosis.
The Journal of surgical research  •  2014  |  View Paper
To determine whether autophagy is required for chemotherapy-induced senescence, reactive oxygen generation induced by Adriamycin was suppressed by N-acetyl cysteine and glutathione , and the induction of ataxia telangiectasia mutated, p53, and p21 was modulated pharmacologically and/or genetically.
Journal of Pharmacology and Experimental Therapeutics  •  2012  |  View Paper
The free …, glutathione and N-acetyl cysteine … accelerated senescence response to Adriamycin in MCF-7 cells as well as in MDA-MB231 and MCF-7/E6 cells, but protect primarily the … cells, indicating that reactive oxygen is unlikely to be directly responsible for Adriamycin toxicity in breast tumor cells.
Biochemical pharmacology  •  2009  |  View Paper
It is believed that GSH plays a role in the aquisition of resistance to anti-cancer drugs, such as a cisplatin, adriamycin , melphalan, or taxol.
Gan to kagaku ryoho. Cancer & chemotherapy  •  1997  |  View Paper
This study implies a role of glutathione and related enzymes in chemoresistance to adriamycin , although this is certainly not the sole mechanism.
Anti-cancer drugs  •  1993  |  View Paper
However, when exposed to a clinically relevant dose of ADR , the GSH content of cell lines that were 'sensitive' decreased, whereas that of cell lines that were 'resistant' increased.
In particular, ADR resistance was found to be closely correlated with the positive changes in absolute GSH AUC following ADR treatment (r = 0.92; P less than 0.01).
These results demonstrate that changes in cellular GSH concentration during treatment may be an important indicator of tumour cell response to ADR.
When this latter factor was included in the analysis, greatly improved correlations were found between GSH kinetic parameters and responses to ADR.
British Journal of Cancer  •  1989  |  View Paper
An increasing body of evidence implies that GSH and these enzymes play important roles in determining the sensitivity of tumours against cytotoxic drugs like quinone antibiotics, in particular adriamycin (Adr).
Carcinogenesis  •  1989  |  View Paper
Cells with high GSH content were more resistant to adriamycin than cells with low GSH content, for example, at 1 log cell kill MLS/bright was 1.6 fold more resistant than MLS/dim.
International journal of radiation oncology, biology, physics  •  1989  |  View Paper
Furthermore, the kinetics of GSH response to ADR varied significantly between cell lines.
Under these conditions, the cytotoxicity of ADR was significantly enhanced by GSH depletion.
NCI monographs : a publication of the National Cancer Institute  •  1988  |  View Paper
Adriamycin treatment markedly depressed the biosynthesis of proteins, purines, pyrimidines and glutathione , and glycolysis, while it enhanced glycerol metabolism of MCF-7S cells.
Metabolomics  •  2013  |  View Paper
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