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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epirubicin
supplement:
Glutathione
Research Papers that Mention the Interaction
“ Epirubicin treatment also decreased glutathione resulting in the induction of apoptosis.”
Progesterone augments epirubicin-induced apoptosis in HA22T/VGH cells by increasing oxidative stress and upregulating Fas/FasL.“Moreover, epirubicin significantly enhanced the phosphorylation of p38 MAPK, and these effects were attenuated by GSH and NAC.”
Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury.“ DXR produced significant elevation in malondialdehyde (MDA) … significantly inhibited the activity of glutathione (GSH) in heart tissue, with a significant rise in the serum levels of lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and reduction in high-density lipoprotein (HDL), indicating acute cardiac toxicity.”
“Furthermore, DXR treatment caused significant increases in the levels of malondialdehyde (MDA), nitric oxide (NO), nitric oxide synthase (NOS) and significant decreases in the levels of reduced glutathione ( GSH ), glutathione-S-transferase (GST), and superoxide dismutase (SOD).”
“ Dororubicin pretreatment caused both a 66% increase in the covalent binding of acetaminophen to hepatic protein at 4 hr, and a further depletion of hepatic GSH , 18% below that induced by acetaminophen alone.”
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