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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epirubicin
supplement:
Formononetin
Research Papers that Mention the Interaction
“Co-incubation of epirubicin with formononetin increased the ROS levels, including hydrogen peroxide and superoxide free radicals.”
“Our results revealed that formononetin significantly enhanced the cytotoxicity of epirubicin.”
“This result indicates that efflux transporter-mediated epirubicin resistance is inhibited at different degrees by the addition of formononetin.”
“This study pioneered in demonstrating that formononetin may potentiate the cytotoxicity of epirubicin in HeLa cells through the ROS-mediated MRP inhibition and concurrent activation of the mitochondrial and death receptor pathways of apoptosis.”
Formononetin potentiates epirubicin-induced apoptosis via ROS production in HeLa cells in vitro.“Co-treatment with other chemotherapy drugs such as bortezomib, LY2940002, U0126, sunitinib, epirubicin , doxorubicin, temozolomide, and metformin enhances the anticancer potential of both formononetin and the respective drugs through synergistic effect.”
Formononetin: A Review of Its Anticancer Potentials and Mechanisms
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