Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“The cardiotoxicity of adriamycin , used in treatment modalities of cancer, is significantly reduced by CoQ10 , apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes.”
Drugs under experimental and clinical research • 1985 | View Paper
“The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM.”
“These data indicate that the antitumor activities of adriamycin could possibly be partly due to inhibition of CoQ 10 -enzymes in electron transfer processes of cell respiration in addition to intercalation within DNA helices.”
Biochemical and biophysical research communications • 1974 | View Paper
“The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR.”
Biochemical and biophysical research communications • 1977 | View Paper
“Therefore, the consumption of both alcohol and alcohol-free beer by rats treated with Adriamycin prevents the inhibition of enzymatic activities of complexes I and IV and the oxidation of coenzymes Q9 and Q10 in rat heart and liver mitochondria.”
“Incubation of hepatocytes with adriamycin induces loss of respiration and mitochondrial potential measured in whole cells by flow cytometry using rhodamine 123 as a probe: concomitant incubation with CoQ10 completely protects both respiration and potential.”
Journal of nutritional science and vitaminology • 1982 | View Paper
“Pretreatment for four days with coenzyme Q10 (COQ10) reduced the acute toxicity in mice treated with adriamycin.”
“The mechanism for this reduction in the acute toxicity may be based upon the prevention by the supplementary COQ10 of the inhibition caused by adriamycin to COQ10-dependent enzymes in cardiac and and other tissues.”