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Last Updated: 4 months ago

Possible Interaction: Epirubicin and Coenzyme Q10

supplement:

Coenzyme Q10

Research Papers that Mention the Interaction

The cardiotoxicity of adriamycin , used in treatment modalities of cancer, is significantly reduced by CoQ10 , apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes.
Drugs under experimental and clinical research  •  1985  |  View Paper
The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM.
Cancer treatment reports  •  1978  |  View Paper
These data indicate that the antitumor activities of adriamycin could possibly be partly due to inhibition of CoQ 10 -enzymes in electron transfer processes of cell respiration in addition to intercalation within DNA helices.
Biochemical and biophysical research communications  •  1974  |  View Paper
The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR.
Gan no rinsho. Japan journal of cancer clinics  •  1984  |  View Paper
Adriamycin and the reference inhibitor of the functionality of CoQ 10 -enzymes at the same concentration gave the same inhibition of biosynthesis.
Biochemical and biophysical research communications  •  1977  |  View Paper
Therefore, the consumption of both alcohol and alcohol-free beer by rats treated with Adriamycin prevents the inhibition of enzymatic activities of complexes I and IV and the oxidation of coenzymes Q9 and Q10 in rat heart and liver mitochondria.
European journal of nutrition  •  2010  |  View Paper
Incubation of hepatocytes with adriamycin induces loss of respiration and mitochondrial potential measured in whole cells by flow cytometry using rhodamine 123 as a probe: concomitant incubation with CoQ10 completely protects both respiration and potential.
Molecular aspects of medicine  •  1994  |  View Paper
Systemic hypotension caused by adriamycin was accelerated by CV-2619 or Q-10.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1982  |  View Paper
The combined use of CoQ10 with adriamycin has been recommended for reduction of the cardiotoxicity that occurs during cancer chemotherapy.
Journal of nutritional science and vitaminology  •  1982  |  View Paper
Pretreatment for four days with coenzyme Q10 (COQ10) reduced the acute toxicity in mice treated with adriamycin.
The mechanism for this reduction in the acute toxicity may be based upon the prevention by the supplementary COQ10 of the inhibition caused by adriamycin to COQ10-dependent enzymes in cardiac and and other tissues.
Research communications in chemical pathology and pharmacology  •  1977  |  View Paper