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Discover Supplement-Drug Interactions
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Last Updated: 4 months ago
drug:
Epirubicin
supplement:
Coenzyme Q10
Research Papers that Mention the Interaction
“The cardiotoxicity of adriamycin , used in treatment modalities of cancer, is significantly reduced by CoQ10 , apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes.”
Research on coenzyme Q10 in clinical medicine and in immunomodulation.“The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM.”
“These data indicate that the antitumor activities of adriamycin could possibly be partly due to inhibition of CoQ 10 -enzymes in electron transfer processes of cell respiration in addition to intercalation within DNA helices.”
Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity.“The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR.”
“ Adriamycin and the reference inhibitor of the functionality of CoQ 10 -enzymes at the same concentration gave the same inhibition of biosynthesis.”
“Therefore, the consumption of both alcohol and alcohol-free beer by rats treated with Adriamycin prevents the inhibition of enzymatic activities of complexes I and IV and the oxidation of coenzymes Q9 and Q10 in rat heart and liver mitochondria.”
Effect of beer consumption on levels of complex I and complex IV liver and heart mitochondrial enzymes and coenzymes Q9 and Q10 in adriamycin-treated rats“Incubation of hepatocytes with adriamycin induces loss of respiration and mitochondrial potential measured in whole cells by flow cytometry using rhodamine 123 as a probe: concomitant incubation with CoQ10 completely protects both respiration and potential.”
“Systemic hypotension caused by adriamycin was accelerated by CV-2619 or Q-10.”
“The combined use of CoQ10 with adriamycin has been recommended for reduction of the cardiotoxicity that occurs during cancer chemotherapy.”
“Pretreatment for four days with coenzyme Q10 (COQ10) reduced the acute toxicity in mice treated with adriamycin.”
“The mechanism for this reduction in the acute toxicity may be based upon the prevention by the supplementary COQ10 of the inhibition caused by adriamycin to COQ10-dependent enzymes in cardiac and and other tissues.”
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