Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Epirubicin and Calcium Supplement

Research Papers that Mention the Interaction

The present data suggest the potency of the calcium ion as an enhancer of ADM.
Current cancer drug targets  •  2015  |  View Paper
In erythrocytes labeled with [32P]orthophosphate 10 microM ADR induced a 1.5-fold increase in the phosphorylation of the Ca2+ pump and when combined with 1 microM PMA the phosphorylation was greatly enhanced (2.3 times that induced by PMA alone).
Archives of biochemistry and biophysics  •  1995  |  View Paper
Adriamycin , paradoxically, appeared to cause a fall in the levels of erythrocyte polyphosphoinositides, but prevented further breakdown induced by calcium loading.
Advances in enzyme regulation  •  1985  |  View Paper
The largest increase in the rate of fusion was observed when calcium ions were also present with adriamycin.
Biochimica et biophysica acta  •  1982  |  View Paper
injections of adriamycin at doses of 2–30 mg/kg until a lethal haemodynamic shock occurred.3.“Low-dose-effects” were reversible within min, … 0.5 mEq/l after doses of 25 mg/kg adriamycin).5.An antagonistic interaction was seen between the cardio-depressant effect of adriamycin … calcium ….
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Dox and epirubicin , which are considered the most cardiotoxic drugs of the anthracycline family, significantly increased the maximal calcium activated tension by 33% (n = 8, P < 0.01) and by 26% (n = 8, P < 0.01) respectively.
Journal of molecular and cellular cardiology  •  1997  |  View Paper
Addition of 1 mM calcium reduced fluorescence quenching by adriamycin maximally by approximately 90%.
Increasing calcium concentrations abolished the activating and most of the inhibitory effects of adriamycin with the above phospholipid substrates.
The Journal of biological chemistry  •  1991  |  View Paper
adriamycin treated rabbits had a lower contraction … controls when maximally activated with calcium , at 11.1(0.9)% shortening (n = 11) v 13.6(0.5)% (n = 14), p less than … with isoprenaline, at 11.6(0.6)% shortening v 13.1(0.4)%, p less than 0.05.
Cardiovascular research  •  1990  |  View Paper
It may be deduced that adriamycin shows its negative inotropic effect by inhibiting the entry of extracellular Ca++ into the myocardial cells and the release of Ca++ from intracellular stores.
Anticancer research  •  1988  |  View Paper
A large single dose (15 mg/kg body wt, ip) of the antitumor agent adriamycin ADR ) caused a marked increase in calcium concentration of submaxillary gland of female mice, and a smaller increase in the parotid gland within 2 days of injection.
Journal of oral pathology  •  1983  |  View Paper
Show More