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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Epirubicin
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“The present results showed that pretreatment with lipoic acid [75 mg/kg body wt/day (ip), 24 h prior to administration of adriamycin ] significantly restored various cellular activity suggesting the antioxidant potential of lipoic acid in ameliorating the hepatotoxicity induced by adriamycin.”
Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model.“The treatment with LA showed significant reduction in the frequency of chromosomal aberrations, DNA strand breaks and apoptosis in bone marrow cells as well as decreased the micronuclei formation in bone marrow and peripheral blood of rats treated with ADR.”
“Pretreatment with LA (35 mg/kg body weight/day i.p.) 24 hours prior to the administration of ADR once a week for a period of 12 weeks was effective in counteracting these biochemical disturbances, thereby minimizing the toxic side effects of ADR.”
“Group IV rats were given lipoic acid 24 h before the administration of adriamycin.”
“The study has highlighted the beneficial effects of lipoic acid pretreatment in reversing the damages caused by adriamycin and thereby bringing about an improvement in the oxidative stress parameters.”
“Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.”
“CONCLUSION This study has highlighted the beneficial effects of LA pretreatment in reversing the damages caused by ADR , by bringing about an improvement in the reductive status of the cell.”
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