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Possible Interaction: Epinephrine and Yohimbine

supplement:

Epinephrine

supplement:

Yohimbine

Research Papers that Mention the Interaction

We conclude that yohimbine increases plasma NE levels by increasing the rate of NE release from sympathetic nerves, and probably increases epinephrine release from the adrenals.
The Journal of clinical endocrinology and metabolism  •  1991  |  View Paper
Ex vivo platelet aggregation in response to epinephrine was inhibited during yohimbine , showing that non-innervated alpha 2-adrenoreceptors were inhibited.
Hypertension  •  1983  |  View Paper
The SPMA cases were strongly associated with insensitivity to YH (in contrast with non-SPMA cases) when epinephrine was used as an agonist.
Platelets  •  2005  |  View Paper
The synergistic interaction of …-5 microM) and epinephrine (0.5-2 microM) … by alpha2-adrenoceptor blocker ( yohimbine ; IC50= 0.4 microM), calcium channel blockers (verapamil and diltiazem with IC50 of 10 and 48 …), PLC inhibitor (U73122; IC50=6 microM) and nitric oxide (NO) donor, SNAP (IC50=1.6 microM)).
Experimental & Molecular Medicine  •  1999  |  View Paper
Aggregation and rise in [Ca2+]i under low shear in the presence of epinephrine was abolished by monoclonal antibodies against A1 domain … Ib, like aggregation and the rise in [Ca2+]i occurred under high shear rate (10,800 s-1), alpha 2-receptor blockade yohimbine completely antagonized … of epinephrine.
Thrombosis research  •  1996  |  View Paper
Plasma norpinephrine (but not epinephrine ) concentrations were increased (100 percent) after oral yohimbine administration.
International journal of obesity  •  1991  |  View Paper
However, epinephrine (in the simultaneous presence of the alpha 2-adrenergic blocking agent, yohimbine ) and isoproterenol were 10 times more potent in stimulating purine release than in elevating cAMP.
The Journal of clinical investigation  •  1990  |  View Paper
Lipolytic sensitivity to isoprenaline (P less than 0.05), and to epinephrine in the presence of yohimbine (P less than 0.0001), was significantly increased in the diabetic subjects with severe autonomic neuropathy, compared to the other study groups.
Journal of internal medicine  •  1990  |  View Paper
This inhibitory effect of epinephrine was removed by adding a specific alpha 2-adrenoceptor antagonist, yohimbine , indicating that the inhibitory effect of epinephrine on cAMP formation was due to alpha 2-adrenoceptor stimulation.
Clinical and experimental hypertension. Part A, Theory and practice  •  1989  |  View Paper
Yohimbine inhibited the epinephrine (10 microM) response in a concentration-dependent manner.
Life sciences  •  1989  |  View Paper
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