Possible Interaction: Epinephrine and Vitamin E

“ Tocopherol lowered daily urinary epinephrine levels and increased the release of vanillylmandelic acid, without changing epinephrine excretion.”

“ Alpha-tocopherol inhibits human platelet aggregation induced by arachidonate sodium, collagen, epinephrine , adenosine diphosphate or thrombin — arachidonate sodium being the most susceptible.”

“Together NBT and vitamin E blocked aggregation by epinephrine , collagen, and thrombin, but permitted a small first wave stimulated by ADP.”

“Pretreatment of tomato extract (1 mg/kg, 2 mg/kg) and vitamin E (50 mg/kg) significantly reduced the malondialdehyde concentration in heart and significantly lowered the serum AST level in adrenaline treated rats.”

“It is shown that a day after introduction of adrenaline which evokes experimental focal myocarditis the level of ubiquinone and vitamin E content in the myocardial mitochondria increases by 56.8 and 122%, respectively.”

“Administration of two doses of vitamin E (50 mg/kg intraperitoneally), given 24 h and 1 h before adrenaline infusion , significantly increased the amount of adrenaline required to produce pathological arrhythmias (control 8.0 +/- 3.0; hypertrophy 7.7 +/- 2.0 micrograms/kg).”

“The data suggest that a combination therapy with vitamin E may allow therapeutic use of higher concentrations of adrenaline required to improve function in failing hearts with a reduced risk of arrhythmias.”

“ EPI had a similar inhibitory potency as ISO, but their potency was several times higher than the potency of alpha-tocopherol (alpha-TOC).”