Possible Interaction: Epinephrine and Vitamin C

“The introduction of AA can inhibit the oxidative polymerization process of EP due to the strong reducibility of AA, resulting in the fluorescence recovery of MQDs at 414 nm and the fluorescence decreasing of PEP-PEI at 522 nm.”

“ Ascorbic acid (1000 μg/ml) in platelet-rich plasma consistently inhibited platelet aggregation with threshold concentrations of ADP, epinephrine , and collagen, but enhanced aggregation with arachidonic acid.”

“Although pretreatment with either vitamin A or vitamin C did not affect the basal malondialdehyde level in control animals, the increase in malondialdehyde level caused by epinephrine administration was significantly reduced by these agents.”

“However, a clinically relevant concentration of ascorbic acid , a competitive inhibitor of COMT, almost completely blocks epinephrine metabolism and increases the bioavailability of epinephrine.”

“ Epinephrine inhibited the effectsof iron and ascorbic acid , while certain amino acids facilitated them.”

“ Ascorbic acid stimulated oxytocin secretion when used alone over a range of concentrations, but was also able to synergize with adrenaline.”

“ Ascorbic acid is used in the laboratory as a stabilizing agent to delay the oxidation of adrenaline solutions.”

“While ascorbic acid itself did not affect the response of the preparation to phrenic nerve stimulation, it significantly reduced the response of the preparation to neostigmine and the augmentation of this response by adrenaline.”

“ Ascorbic acid added to the medium prolonged the lifetime of epinephrine but did not alter the degree of diminution of PNMT.”

“It was observed that ascorbic acid pretreatment prevented the eosinopenia and the depletion of adrenal cholesterol typical of acute epinephrin stress (Bacchus and Toompas, 1951).”

“This paper reports data which indicate that ascorbic acid prevents the eosinophil response to epinephrin , but not to corticotrophin.”

“Morphine, meperidine, and methadone as well as epinephrine when injected into animals for a period of time increased the ascorbic acid catalyzed oxidation of linolenic acid in the brain as measured by the TBA test.”