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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Vincristine
Research Papers that Mention the Interaction
“Abstract We have demonstrated … in vitro addition of vincristine to human platelets: 1) inhibits aggregation induced by arachidonic acid, epinephrine , collagen, thrombin and ADP; 2) inhibits arachidonic acid conversion to thromboxane A 2 ; and 3) inhibits generation of thromboxane A 2 upon stimulation by mechanical agitation, collagen, or thrombin.”
In vitro effects of vincristine on arachidonic acid metabolism in human platelets and rat arterial tissue.“ Vincristine induced unobtainable second phase aggregation to epinephrine in 67%, 38%, 30% and to ADP in 53%, 13%, 33% of the patients 1 week, 2–3 weeks and 4 weeks respectively after administration.”
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