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Possible Interaction: Epinephrine and Verapamil

supplement:

Epinephrine

Research Papers that Mention the Interaction

V significantly decreased resting epinephrine (P = .05) and there was a tendency for V to reduce norepinephrine (P = .07) and dopamine (P = .08).
American journal of hypertension  •  1993  |  View Paper
The SNAP, diltiazem and verapamil inhibited the platelet aggregation induced by A23187 and epinephrine with IC50 value of 0.5 microM, 50 microM and 22 microM respectively.
Journal of Ayub Medical College, Abbottabad : JAMC  •  2005  |  View Paper
The synergistic interaction of …-5 microM) and epinephrine (0.5-2 microM) was inhibited by alpha2-… (yohimbine; IC50= 0.4 microM), calcium channel blockers ( verapamil and diltiazem with IC50 of 10 and 48 mM, respectively), PLC inhibitor (…=6 microM) and nitric oxide (NO) donor, SNAP (IC50=1.6 microM)).
Experimental & Molecular Medicine  •  1999  |  View Paper
Verapamil shortened the action potential duration to 355 +/- 28 ms (p < 0.01 vs. epinephrine ) and decreased the dispersion to 44 +/- 19 ms (p < 0.05 vs. epinephrine).
Journal of the American College of Cardiology  •  1995  |  View Paper
Diltiazem and verapamil inhibited aggregation caused by adrenaline 5 microM and collagen 2 micrograms/ml, but only at concentrations far in excess of those seen in clinical use.
Thrombosis and haemostasis  •  1989  |  View Paper
Verapamil inhibits the epinephrine contribution to the aggregation response by blocking alpha 2-adrenergic receptor binding.
Circulation  •  1986  |  View Paper
In vivo verapamil significantly decreased platelet aggregation induced by ADP and epinephrine while no changes were observed after arachidonic acid.
International angiology : a journal of the International Union of Angiology  •  1985  |  View Paper
Epinephrine sensitive phosphorylation is completely inhibited following pretreatment with verapamil or nitrendipine.
Journal of receptor research  •  1984  |  View Paper
Verapamil (0.5 micrograms/ml) in this study inhibited platelet aggregation induced by threshold amounts of ADP, AA, and epinephrine.
Thrombosis research  •  1983  |  View Paper
Our findings suggest that the actions of verapamil in this regard are complex; there may be competitive inhibition of epinephrine binding as well as a blockade of epinephrine-induced calcium flux.
The action of verapamil could be overcome by higher concentrations of both epinephrine and calcium.
Thrombosis research  •  1982  |  View Paper
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