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Last Updated: 2 years ago

Possible Interaction: Epinephrine and Vasoconstrictor Agents

Research Papers that Mention the Interaction

The forearm vasoconstrictor response to lower body negative pressure (LBNP), a reflex stimulus to norepinephrine release, can be augmented by a prior brachial artery infusion of epinephrine.
Hypertension  •  1990  |  View Paper
Preparations including adrenaline were also observed to intensify local nasal vasoconstriction resulting in a better operative field.
Clinical otolaryngology and allied sciences  •  1988  |  View Paper
It was especially notable that carticaine without vasoconstrictor was not able to produce reliable analgesia, while only a minute amount of adrenalin (3.3 μg/ml) improved the parameters radically.
International journal of oral surgery  •  1974  |  View Paper
Additional vasoconstrictive properties of epinephrine on >-1 adrenoreceptors (among epinephrine’s other potential analgesic properties such as agonist activity of the >-2A adrenoreceptor) prolong the clinical duration of local anesthetic nerve blocks.
Regional Anesthesia & Pain Medicine  •  2010  |  View Paper
A higher number of patients receiving epinephrine required vasopressors and mechanical ventilation prior to the event compared to those not receiving epinephrine.
Resuscitation  •  2020  |  View Paper
It is worth noting that the vasoconstrictive effects of epinephrine can take up to 15 min to take effect.
Clinical and experimental dermatology  •  2012  |  View Paper
Limited cardiac output during prolonged resuscitation and severe vasoconstriction after large doses of epinephrine and vasopressors might both contribute to the compromised mesenteric perfusion.
The American journal of emergency medicine  •  2005  |  View Paper
Epinephrine 2.5 microg ml(-1) significantly reduced the responses to clinical doses of both drugs (P<0.001), producing net vasoconstriction.
British journal of anaesthesia  •  2005  |  View Paper
In the experimental arm, the vasoconstrictor response to LBNP was 65% greater 30 min after the adrenaline infusion (P = 0.075), whereas the response to intra-arterial noradrenaline decreased by 36% (P greater than 0.1).
Journal of hypertension  •  1990  |  View Paper
The dosage of adrenergic vasoconstrictors should be limited and gingival retraction cord containing epinephrine avoided entirely.
Journal of the American Dental Association  •  1988  |  View Paper
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