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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Urethane
Research Papers that Mention the Interaction
“It has been recognized for some time that cardiac and respiratory function is depressed at larger urethane doses ( 1.5 g/kg) and that even smaller urethane doses will produce a variety of endocrine effects and increase blood levels of glucose and epinephrine (2,5,6).”
Urethane: help or hindrance?“ Urethane caused an elevation of plasma adrenaline , and yohimbine reduced the elevation.”
“In chronically catheterized rats, diethyl ether, ketamine and urethane increased plasma adrenaline (A) and noradrenaline (NA) concentrations, indicating that these drugs stimulate both neurosympathetic and adrenomedullary functions.”
“Furthermore, urethane increases the central drive to the adrenal medulla and this leads to the secretion of epinephrine.”
“ Adrenaline induced dose-related falls in blood pressure and heart rate in both conscious and urethane anaesthetised rats.”
“The injection of urethane and adrenalin changed the components of the DCR markedly)-.”
Areagraphy of the direct cortical response.“ Urethan reduced lethal toxicity of epinephrine ; with increase of dose of epinephrine, reduction of toxicity was less.”
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