Possible Interaction: Epinephrine and Tyrosine

“Interestingly, clustering of nephrin induced also tyrosine phosphorylation of a 46 kD protein that was as well found to be coimmunoprecipitated with nephrin. ”

“RESULTS Clustering of nephrin induced its own tyrosine phosphorylation.”

“ Adrenaline also increases type 2B vWF-elicited tyrosine phosphorylation of proteins with apparent molecular masses of 60 and 80 kDa.”

“Taken together, our results suggested that the potentiation by epinephrine may be mediated via enhancement of tyrosine phosphorylation and Syk activation, in part through a decrease of intracellular cAMP levels.”

“ Tyrosine ingestion induced within 45 min a significant but short-lasting (approximately 30 min) increase in plasma concentrations of NE, EPI , and DA and a coincident decrease in plasma DOPAC levels.”

“A single … dose of tyrosine (100 or 150 mg/kg) caused significant … in urinary levels of norepinephrine (NE), epinephrine ( E ), dopamine (DA), 3-methoxy-4-hydroxyphenylglycol (MHPG), vanilmandelic acid (VMA), and homovanillic acid (HVA) during the first 2 hr after its ingestion; water administration failed to produce such changes.”

“In connection with the problem of the possible role played by the … on substances which are capable of abnormally intensifying the vasoconstrictor power of epinephrine in the mesentery of the rat and the perfused rabbit's ear, … from the kidneys and other tissues, as well as hypertensin and tyrosin (…).”

“show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli.”

“Our study suggests that tyrosine phosphorylation of nephrin by regulating F-actin formation may be important for the maintenance of normal podocyte morphology and function.”

“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine, epinephrine , norepinephrine, serotonin, ergothioneine, thiohistidine and dichlorophenol.”

“10(-7) M adrenaline significantly increased the total amount of muscle tyrosine during 40 min of stimulation with 50 Hz (I s min 1) pulse trains.”