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“Interestingly, clustering of nephrin induced also tyrosine phosphorylation of a 46 kD protein that was as well found to be coimmunoprecipitated with nephrin. ”
“RESULTS Clustering of nephrin induced its own tyrosine phosphorylation.”
“Taken together, our results suggested that the potentiation by epinephrine may be mediated via enhancement of tyrosine phosphorylation and Syk activation, in part through a decrease of intracellular cAMP levels.”
“ Tyrosine ingestion induced within 45 min a significant but short-lasting (approximately 30 min) increase in plasma concentrations of NE, EPI , and DA and a coincident decrease in plasma DOPAC levels.”
The Journal of clinical endocrinology and metabolism • 1983 | View Paper
“A single … dose of tyrosine (100 or 150 mg/kg) caused significant … in urinary levels of norepinephrine (NE), epinephrine ( E ), dopamine (DA), 3-methoxy-4-hydroxyphenylglycol (MHPG), vanilmandelic acid (VMA), and homovanillic acid (HVA) during the first 2 hr after its ingestion; water administration failed to produce such changes.”
“In connection with the problem of the possible role played by the … on substances which are capable of abnormally intensifying the vasoconstrictor power of epinephrine in the mesentery of the rat and the perfused rabbit's ear, … from the kidneys and other tissues, as well as hypertensin and tyrosin (…).”
The Journal of clinical investigation • 1950 | View Paper
“show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli.”
“Our study suggests that tyrosine phosphorylation of nephrin by regulating F-actin formation may be important for the maintenance of normal podocyte morphology and function.”
“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine, epinephrine , norepinephrine, serotonin, ergothioneine, thiohistidine and dichlorophenol.”