Possible Interaction: Epinephrine and Tyrosine

“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine, epinephrine , norepinephrine, serotonin, ergothioneine, thiohistidine and dichlorophenol.”

“ Adrenaline also increases type 2B vWF-elicited tyrosine phosphorylation of proteins with apparent molecular masses of 60 and 80 kDa.”

“Taken together, our results suggested that the potentiation by epinephrine may be mediated via enhancement of tyrosine phosphorylation and Syk activation, in part through a decrease of intracellular cAMP levels.”

“ Tyrosine ingestion induced within 45 min a significant but short-lasting (approximately 30 min) increase in plasma concentrations of NE, EPI , and DA and a coincident decrease in plasma DOPAC levels.”

“In connection with the problem of the possible role played by the … on substances which are capable of abnormally intensifying the vasoconstrictor power of epinephrine in the mesentery of the rat and the perfused rabbit's ear, … from the kidneys and other tissues, as well as hypertensin and tyrosin (…).”

“10(-7) M adrenaline significantly increased the total amount of muscle tyrosine during 40 min of stimulation with 50 Hz (I s min 1) pulse trains.”

“Low doses of adrenaline (0.04 - 0.16 mg/kg, intraperitoneally) caused a 30 per cent decrease in plasma concentrations of tyrosine , while high doses (0.63 - 1.25 mg/kg, intraperitoneally) caused an increase in plasma tyrosine to nearly 200 per cent of the controls.”

“Norepinephrine, epinephrine and clonidine have higher affinities for Y and X sites than for P site, and indoramin has a much higher affinity for P site.”