Possible Interaction: Epinephrine and Tyramine

“The amnestic effect of posttraining adrenaline or tyramine is counteracted by the administration of adrenaline or tyramine prior to testing: each drug has a greater antiamnestic effect against itself than against the other drug.”

“The antiamnestic effect of tyramine and adrenaline is antagonized by the simultaneous administration of prazosin or yohimbine, but not by that of propranolol.”

“cardiac stimulating effects of dopamine and tyramine were strongly depressed, and those of noradrenaline, adrenaline and isoprenaline were reduced to some extent.”

“MA slightly potentiated the effects of norepinephrine, epinephrine and reduced the effects of tyramine on the responses of the cat nictitating membrane and blood pressure, but did not potentiate the effects of norepinephrine on the guinea-pig vas deferens and rabbit pulmonary artery.”

“2 Noradrenaline and adrenaline restored the chronotropic response to tyramine , the degree of restoration depending on the concentration of the restorative amine used.”

“However, in the presence of tyramine, adrenaline release was greater than noradrenaline release.”

“Reserpine pretreatment made more apparent the “facilitation” which is sometimes observed on recovery from blockade after single injections of epinephrine and tyramine.”

“Further it was found that the constrictor effect of a small dose of tyramine was greatly enhanced by adding adrenaline to the circulation.”