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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Epinephrine
drug:
Triiodothyronine
Research Papers that Mention the Interaction
“ RESULTS Addition of epinephrine prolonged the duration of analgesia from 103.8 +/- 28.2 minutes to 142 +/- 54.3 minutes and lowered the median cephalad level of sensory block from T3 to T6.”
Ambulatory Combined Spinal‐Epidural Analgesia for Labor: Influence of Epinephrine on Bupivacaine‐Sufentanil Combination“ Epinephrine was found to increase urinary I131 (primarily as iodide) after the administration of labeled L-thyroxine, D-thyroxine and L-triiodothyronine as compared to the I131 excretion after injection of these thyronines without epinephrine.”
“The heart rate and the lipolytic effect of epinephrine on adipose tissue were increased 3 hr after giving 45 μg of T3 intravenously and at 6 hr after giving 15 or 45 ng of T3 subcutaneously.”
STUDIES ON THE EARLY EFFECTS OF THYROID HORMONES.“Acute administration of T3 after epinephrine exposure lowered contractile performance from 136.2 +/- 15.5% to 102 +/- 8.2 %, after 10 minutes.”
Acute triiodothyronine administration does not reverse depressed contractile performance following catecholamine exposure in isolated rat cardiomyocytes.“Addition of isoproterenol or of epinephrine further increases the frequency at all T3 concentrations tested.”
“After induction of myocardial depression by epinephrine exposure T3 accelerated the intracellular calcium transients and reduced diastolic calcium.”
“However, the effect of T(3 ) was clearly potentiated by the concomitant addition of epinephrine , norepinephrine, and possibly isoproterenol, whereas terbutaline and phenylephrine were without effect.”
“Testosterone, dihydrotestosterone, and epinephrine stimulated the accumulation of cyclic 3′,5′-AMP 60–70% after preincubation of the cells with triiodothyronine while androstenedione and progesterone had no effect under the same conditions.”
“Pretreatment of hypophysectomized rats with triiodothyronine (T3, 5 μg/rat) also markedly potentiated the lipolytic response of segments of adipose tissue to epinephrine and theophylline when tested in vitro 16 hr later.”
“It is concluded that epinephrine and another 4 chemically related compounds with 2 OH groups at the benzene ring specifically inhibit enzymatic deiodination of thyroxine and triiodothyronine at least in vitro.”
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