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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Trifluoperazine
Research Papers that Mention the Interaction
“The first phase of aggregation by a minimum concentration of epinephrine was completely inhibited by 100 microM trifluoperazine , and the first phase of aggregation induced by ADP, thrombin or A23187 was decreased by 300 microM trifluoperazine.”
“We have found that aggregation by minimum concentrations of collagen and arachidonic acid, and second phase aggregation by minimum concentrations of ADP, thrombin, epinephrine and the calcium ionophore A23187 were inhibited by 40-60 microM trifluoperazine.”
Effects of trifluoperazine on platelet activation.“The calmodulin inhibitors trifluoperazine and W7 (10(-4) M) prevented the stimulation of the exchanger induced by carbachol or epinephrine , but W7 could not block the stimulation produced by A23187 arguing against the involvement of calmodulin in this effect.”
Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase C.“The effects of adrenaline , prostaglandin E2, dibutyryl cyclic AMP (DBcAMP) and the Ca ionophore A23187 were inhibited by mepacrine, trifluoperazine and bumetanide.”
“4) Trifluoperazine , at concentrations that prevent stimulation by epinephrine of gluconeogenesis, was as effective as phentolamine in blocking the binding of [3H]epinephrine to intact hepatocytes. (”
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