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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Epinephrine and Trifluoperazine

Research Papers that Mention the Interaction

The first phase of aggregation by a minimum concentration of epinephrine was completely inhibited by 100 microM trifluoperazine , and the first phase of aggregation induced by ADP, thrombin or A23187 was decreased by 300 microM trifluoperazine.
We have found that aggregation by minimum concentrations of collagen and arachidonic acid, and second phase aggregation by minimum concentrations of ADP, thrombin, epinephrine and the calcium ionophore A23187 were inhibited by 40-60 microM trifluoperazine.
Thrombosis research  •  1985  |  View Paper
Trifluoperazine an alpha-adrenoceptor antagonist and anticalmodulin agent, concealed the inhibitory effect of epinephrine in a concentration dependent manner, whereas theobromine a cAMP-phosphodiestrase inhibitor did not have any significant effect.
European journal of pharmacology  •  2006  |  View Paper
Trifluoperazine (10 mumol/L), presumably an inhibitor of calcium-dependent protein kinase, abolished the effect of epinephrine (13.6 +/- 0.22 v 16.0 +/- 0.17).
Metabolism: clinical and experimental  •  1983  |  View Paper